1H Nuclear magnetic resonance based targeted profiling of metabolic responses induced by DNA damaging agents and PARP inhibition in MCF-7 cells
نویسندگان
چکیده
Background Maintaining DNA integrity is essential for cell survival and proper functioning. Therefore, many cancer therapies, including radiotherapy and several chemotherapeutic drugs, induce damage to the DNA leading to genomic instability [1]. There are several DNA damage responses (DDRs) which can be activated depending on the type and the extent of DNA damage [1]. These responses involve detection of the damage by several proteins including, poly (ADP-ribose) polymerase (PARP), which can directly or indirectly affect metabolism [1].
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2014